The module begins by examining the Historical review and revolution of Human Resource and Crew Management. Follows, the structure of Crew department and its cooperation with other departments in a Shipping Company. Its daily operation is exhibited in details. Presenting and analysing the variable CBAs and options that the ITF offers, is one of the main subjects. We continue with elaborating further on the major aspects related to seafarers, such as Documentation, Recruitment, Retention, Promotion, Evaluation and Training. We discuss the collaboration of Ship Management Companies with Manning agencies or with their own Manning branches abroad. Requirements of STCW and MLC Conventions are analysed and applied within the Crew Management context. The impact of vessel operations and crisis situations such as pandemic outbreak on the management of seafarer mental health is outlined together with initiatives and procedures for mitigation.